Classic Digital Bio

Theo chocolate is situated in a neighborhood called Fremont, in the city of Seattle, in the former Redhook brewery. I used to consult for Redhook in my microbiology days, when I had access to a -80°C freezer and a proper microscope, so the building has a comfortable feel and some pleasant memories. These days the bar is gone and the aromas are more like roasting coffee than brewing beer. Most of machinery, though, is surprisingly similar. The equipment is very much the same as the equipment you'd find in many kinds of biotech manufacturing ... Read more
This wasn't in the lab, but it was an accident, and it was funny later on. Normally, I wouldn't think twice about storing bacterial cultures in a refrigerator. After all, bacteria on a petri plate, inside of a plastic bag, are kind of stuck. They can't get out of the plates, and even if they did, they certainly can't crawl out of a plastic bag. I thought soil bacteria, on agar plates, were mostly harmless. I was wrong. ... Read more
How do you go about researching a genetic disease? This multi-part series explores how digital resources can be used to learn about Huntingtin's disease. Reposted and updated from the original DigitalBio. A bit of background Alice's Restaurant is a movie with an unforgettable song that mostly revolves around Arlo Guthrie hanging out with his friends. Somewhere in the movie, the conversation turns to Woody, and someone asks the question that no one wants to touch. Does Arlo's girlfriend know about Huntington's? ...dead silence... Now, I did see the movie ... Read more
Reposted from the original Digitalbio. About a decade ago, I took a fascinating summer course at the UW on bioethics. We read about the Nuremburg trials and the Geneva conventions. We learned about horizon problems and eugenics. And we discussed lots of challenging scenarios with genetic testing, autonomy, family relationships, and the problems faced by people seeking to have children, trying to get insurance, or looking for a job. So naturally, when I started a biotechnology course for non-science majors (Biotechnology and Society) at our community college, I used many of those ... Read more
No one in a life science-related industry or research lab, in Western Washington, is safe at this time of year. Surely, you're joking! No, seriously, there are teachers and science enthusiasts everywhere looking to sign you up! And don't call me "Shirley." Sign me up? That's right, it's time to prepare for the BIOTECH EXPO This is the Western Washington version of the science Olympics! Those science enthusiasts are out scouting for anyone who does something related to science or a life-science industry to act as an advisor (sort a ... Read more
Why is an eye, an eye and a nose, a nose? Why do different cells create different kinds of tissues when all the cells in a single organism start out with the same set of instructions (aka DNA)? Head, Shoulders, Knees, and Toes is a learning activity that helps students discover, for themselves, that certain genes are expressed in some tissues but not in others. My goal here, as part of our NSF-funded project, is to show how students can learn biology by doing science with bioinformatics tools. If ... Read more
Awhile back Chemical & Engineering News published a fascinating article called "The Secret Life of Plant Crystals" with some wonderful photos of calcium oxalate crystals. Special cells (called "idioblasts") produce these crystals, with shapes that are unique to each type of plant. Even though 75% of flowering plants make these crystals, no one knows why they make them and in fact, their functions may be as diverse as their ... Read more
Modified from the original post. i-e0bb5e70117b600f9bf2a270d7bc69f1-telomere1.gifPlaying around with molecular structures is one of the more entertaining activities that you can do with digital biology. I've become totally entranced with molecular structures, both because they're a fascinating art form and because every structure has its own story. I learned this because I ended up writing 69 different structure stories for ... Read more
Reposted and slightly modified from Classic DigitalBio. Some people say that science takes the magic out of everyday life. Not me! I've learned some things by reading Science (1) that might give some people nightmares, especially young children. Remember that scene in "The Wizard of Oz" when the trees get ticked off and start hurling apples at poor Dorothy? Real plants do defend themselves. Those "Wizard of Oz" trees would really defend themselves by giving poor Dorothy a tummy ache Pardon me a moment while I apologize to enforcers of precise ... Read more
i-1b1eed7059f467a3112cb1b7920b3402-flower.gifA long time ago, I saw a Star Trek episode where the crew encountered aliens who lived at a different frequency. I may have this backwards, but I think the aliens moved so quickly that no one knew they were there. And until problems struck, our heroes were happily oblivious to the existence of the others. The Plants In ... Read more

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