Lesson Four: Using Bioinformatics to Analyze Protein Sequences

In this lesson, students perform a paper exercise designed to reinforce student understanding of the complementary nature of DNA and how that complementarity leads to six potential protein reading frames in any given DNA sequence. They also gain familiarity with the circular format codon table. Students then use the bioinformatics tool ORFinder to identify the reading frames in their DNA sequence from Lesson Two and Lesson Three, and to select the proper open reading frame to use in a multiple sequence alignment using their protein sequences. In Lesson Four, students learn how biological anthropologists might use bioinformatics tools in their career.

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