DNA Binding Lab Collection

Investigate structures of DNA and determine if other molecules (protein or other chemicals) are bound in the major groove of the DNA or the minor groove.  Use this collection of structures to see how molecules interact with DNA.  Both proteins and drugs bind to specific sequences in DNA by recognizing the three dimensional shapes.  When proteins bind to DNA, they can modify the DNA structure, repair DNA, or copy information.  When anti-cancer drugs bind DNA, they can block DNA replication.  

Download Instructions for the DNA Binding Lab.

Download the worksheet for the DNA Binding Lab.

Download the DNA Binding Lab glossary.

Learn more about investigating DNA structure in Exploring Molecular Structures.

Watch a short video to see how this works: Major vs minor groove


Structures in the collection

Type Description Download structure
An MW Collection

To view the collection, you will need to download and install the iPad version of Molecule World.  Once Molecule World is installed on your iPad, return to this page and download the entire DNA Binding Lab collection at once by clicking the mwc file.

Binary Data DNA_Binding_Lab.mwc
MMDB

A double-stranded DNA molecule.  Hydrogens are shown because this structure was solved by NMR.

Binary Data Example_DNA.cn3.gz
MMDB

A double-stranded DNA molecule. Hydrogens are not seen because this structure was solved by X-ray diffraction.

MMDB

A double-stranded DNA molecule with a protein bound in the major groove.

MMDB

A double-stranded DNA molecule with a drug bound in the minor groove.

MMDB

Unknown 01:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 02:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 03:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 04:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 05:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 06:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 07:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 08:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 09:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 10:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 11:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 12:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 13:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 14:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 15:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 16:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 17:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 18:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 19:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 20:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 21:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 22:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 23:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 24:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 25:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 26:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 27:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 28:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 29:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 30:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 31:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 32:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 33:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 34:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 35:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 36:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 37:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 38:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 39:  A double-stranded DNA molecule with a bound substance.

MMDB

Unknown 40:  A double-stranded DNA molecule with a bound substance.

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